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Among males, those who had at least one sibling of each gender with a history of premarital childbearing had the lowest probability of drug dependence remaining sexually inexperienced throughout the teenage years (Figure 3). In both the male and female analyses, log-rank drug dependence tests of homogeneity found statistically significant differences among the study groups. Differences among sibling categories seem more pronounced for males than for females. Within each drug dependence of the four sibling categories, males' probability of remaining sexually inexperienced tended to be lower than that for females through about middle adolescence. Thereafter, females' probability tended to be lower than that of males. The one exception was participants with one or more brothers, but no sisters, with a history of premarital childbearing: In that study group, males' probability of never having had sex remained lower than that for females throughout late adolescence and early adulthood. Multivariate Cox Regression Analyses Multivariate Cox regressions with backward selection were conducted for each gender to examine the association between sibling category and respondents' initiation of sex by age 17—the median age at first sex in the sample—and by age 24, each in the presence of other potential explanatory variables.
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